The most expensive part of any human-piloted space exploration is the return trip. Nobel prize winning physicist Gerard ‘t Hooft proposes sending humans to Mars on a one way trip:
It would not surprise me if it takes Mars One more than 10 years to put the first humans on Mars, and I can imagine it will cost more than the $6 billion currently envisioned. I have always been careful about those claims. If the project fails, my reputation may sustain some damage, but I am pretty sure I will survive that. Younger scientists, with their careers ahead of them, might run a bigger risk in that respect. Then again, I do not see how it could be held against you if you were to take part in technological design studies or in addressing various scientific issues.